Seminar Series

The goal of the Wells Brain Tumor Center Seminar Series is to bring together the interdisciplinary UF research communities to discuss and address contemporary issues in neuro-oncology and immunotherapy. The platform is designed to provide faculty and students the opportunity to hear from leading researchers and to foster discussion and collaboration.

Format: Every month, seminar attendees will hear on a weekly rotation: i) Laboratory presentation, ii) Journal club discussion, iii) External guest speaker lecture, and iv) Book club discussion.

When: Fridays; 12:00-1:00pm EST

Where: Zoom (link provided by email)

For additional information, please contact Jennifer Bergeron at 352-294-8538 or jennifer.bergeron@neurosurgery.ufl.edu

Spring 2022 Schedule

Dates Host Speaker/author forum talk title
4/8/2022 Carlos Rinaldi-Ramos, PhD Angelie Rivera Rodriguez, PhD, University of Florida Lab presentation Therapeutic Efficacy of Adoptively Transferred T Cells Labeled with Optimized Magnetic Particle Imaging Tracer
4/15/2022 Carlos Rinaldi-Ramos, PhD Hayden Good, PhD candidate, University of Florida Journal Club Tomographic magnetic particle imaging of cancer targeted nanoparticles
4/22/2022 Christina Von Roemeling, PhD Amy Lam, PhD, ClearLight Biotechnologies Guest speaker Tissue Clearing, 3D IHC, and Imaging with ClearLight Biotechnologies
4/29/2022 Carlos Rinaldi-Ramos, PhD Israt Alam, PhD, Stanford University Guest speaker Imaging T cell activation markers using immunoPET
5/6/2022 Gregory Sawyer, PhD Gregory Sawyer, PhD, University of Florida Lab presentation iVITA: in Vitro ImmunoTherapy Assays
5/13/2022 Michalina Janiszewska, PhD Michalina Janiszewska, PhD, University of Florida Lab presentation Mapping tumor heterogeneity in glioblastoma
5/20/2022 Gregory Sawyer, PhD Duy Nguyen, PhD Journal Club Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Summer 2022 Schedule

DATES HOST SPEAKER/AUTHOR FORUM TALK TITLE
6/3/2022 Paul Castillo, MD Paul Castillo, MD, University of Florida Lab presentation Sensitizing surface antigen negative tumors to CAR T cells using RNA-NP vaccine
6/10/2022 Wells Brain Tumor Center Shirzad Chamine Book club Positive Intelligence: Why Only 20% of Teams and Individuals Achieve Their True Potential and How You Can Achieve Yours
6/17/2022 Maryam Rahman, MD Mark Rosenblum, MD, Henry Ford Health System Guest speaker Neurosurgery’s Impact in Neuro-oncology — Lessons Learned Over 50 Years
6/24/2022 Jeffrey Harrison, PhD Jeffrey Harrison, PhD, University of Florida Lab presentation Glioma:myeloid cell interactions
7/8/2022 Jeffrey Harrison, PhD Gregory Takacs, University of Florida Journal Club Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy
7/15/2022 Christina Von Roemeling, PhD Rajappa Kenchappa, PhD, Mayo Clinic College of Medicine Guest speaker Combination of Kinase Inhibitors to Treat Glioblastoma and Prevent Development of Tumor Resistance
7/29/2022 Matthew Sarkisian, PhD Matthew Sarkisian, PhD, University of Florida Lab presentation Primary cilia as a novel venues for promoting immunosuppression in GBM
8/5/2022 Loic Deleyrolle, PhD Nicole Golden, PhD, Nanostring Guest speaker Resolving Tissue Heterogeneity with Flexible, High-Plex Spatial Multiomics
8/12/2022 Elias Sayour, MD, PhD Jeff Li, PhD & Hannah Schuyler, Rosalind Guest speaker ROSALIND: the most advanced collaborative bioinformatics platform
8/19/2022 Matthew Sarkisian, PhD Joshua Breunig, PhD, Cedars-Sinai Medical Center Guest Speaker Expanding the zoo and feature set of MADR brain tumor models
8/26/2022 Elias Sayour, MD, PhD Anna DeVries, University of Florida Lab Presentation Establishing the cross-talk mechanisms between innate and adaptive immunity following systemic mRNA vaccination

Fall 2022 Schedule

Dates HOST SPEAKER/AUTHOR FORUM TALK TITLE
9/2/2022 David Tran, MD, PhD David Tran, MD, PhD, University of Florida Lab Presentation Novel Mechanisms of Action and Resistance in Tumor Treating Fields
9/9/2022 John Ligon, MD Rosendra Kaplan, MD, NCI Guest speaker Genetically Engineered Myeloid Cells (GEMys) to Rebalance Dysregulated Microenvironments
9/16/2022 David Tran, MD, PhD Son Le, PhD, University of Florida Lab Presentation Netzen – application of AI and network in biological problems
10/14/2022 John Ligon, MD Sneha Ramakrishna, MD, Stanford University Guest speaker Leveraging reverse translation to advance CAR T cell therapy in brain tumors and beyond
10/21/2022 Duane Mitchell, MD, PhD Ranjan J. Perera, PhD, Johns Hopkins Guest speaker The long non-coding RNA lnc-HLX-2-7 as a potential therapeutic target ingroup 3 medulloblastoma
10/28/2022 Loic Deleyrolle, PhD Dennis Watson, PhD, Cleveland Clinic Guest speaker Mitochondrial transfer from astrocytes enhances glioblastoma tumorigenicity
11/4/2022 Christina Von Roemeling, PhD Dereck Wainwright, PhD, Northwestern University Guest speaker Aging, immunotherapy, and glioblastoma in adults: Targeting the clock to improve survival
12/8/2022 Bently Doonan, MD Bently Doonan, MD, University of Florida Lab Presentation A Discussion on the results of DCVax-L(R): Moving treatment forward or clinical trial smoke and mirrors?
12/16/2022 Michalina Janiszewska, PhD Stephen Zorc, PhD Journal Club

Spring 2023 Schedule

Dates HOST SPEAKER/AUTHOR FORUM TALK TITLE
1/20/2023 Wells Brain Tumor Center Duane Mitchell, MD, PhD, University of Florida Annual report and vision statement Wells Brain Tumor Center: 2023 and Beyond
1/27/2023 Duane Mitchell, MD, PhD Mohammed Gbadamosi, PhD, University of Florida Journal Club A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response
2/3/2023 Duane Mitchell, MD, PhD Christina von Roemeling, PhD, University of Florida Lab Presentation The IRAK-4 inhibitor Emavusertib (CA-4948) for the treatment of primary CNS lymphoma
2/17/2023 Frank Bova, PhD Matthew Frain, University of Florida Journal Club Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution
2/24/2023 Frank Bova, PhD Matthew Frain, University of Florida Lab Presentation Development and efficacy of stereotactic murine laser interstitial thermotherapy system2/24/2023Frank Bova, PhDMatthew Frain, University of FloridaLab Presentation
3/3/2023 Maryam Rahman, MD Anjali Chauhan, PhD, University of Florida Journal Club A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
3/10/2023 Maryam Rahman, MD Maryam Rahman, MD , University of Florida Lab Presentation “Glioblastoma: Overcoming Treatment Failure.”
3/31/2023 Mohammed Gbadamosi, PhD Erik Marchese (Mission Bio) / Andrew Ressler (Duke) Guest speakers MB solutions for solid tissue
4/14/2023 Carlos Rinaldi-Ramos, PhD Esteban G. Bermudez, University of Florida Journal Club An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma
4/28/2023 Loic Deleyrolle, PhD Justine Johnson, Nanolive, Inc Guest Speaker Nanolive Live Cell Analytics: Label-free 4D imaging at High Resolution
5/5/2023 Carlos Rinaldi-Ramos, PhD Bo Yu, University of Florida Lab Presentation Tracking Dendritic Cell Vaccination Using Magnetic Particle Imaging
5/12/2023 Wells Brain Tumor Center Tim Fung, BioRender Workshop Top tips for better graphical abstracts webinar
5/19/2023 Wells Brain Tumor Center Timothy P. Spicer, Ph.D, UF Scripps Lab Presentation Chemoresponse Profiling Using 3D Primary Tumor Models
5/26/2023 Loic Deleyrolle, PhD Amy Johnson, Nanostring Guest Speaker Introduction to the CosMx Spatial Molecular Imager

Summer 2023 Schedule

Dates HOST SPEAKER/AUTHOR FORUM TALK TITLE
6/2/2023 Wells Brain Tumor Center Chris Fleming, PhD, CYTEKBio Guest Speaker High Quality Multicolor Flow Cytometry: Seeing the WholePicture Through Full Spectrum ProfilingTM (FSPTM)
6/16/2023 Wells Brain Tumor Center Jens Eberlein, PhD, Lumicks Guest Speaker Cell Avidity – A crucial biomarker for predicting effector cell function
6/23/2023 Loic Deleyrolle, PhD Prajwal Rajappa, M.D., M.S, The Ohio State University Guest Speaker Developing Precision Immunotherapies to Reprogram the Glioma Tumor Microenvironment
7/14/203 Wells Brain Tumor Center Brian P. Moran Book Club The 12 week Year:Get More Done in 12 Weeks than others do in 12 Months
7/21/2023 Jeffrey Harrison, PhD Matthew Sarkisian, PhD, University of Florida Lab Presentation TTFields ‘shocking’ effect on glioma primary cilia
7/28/2023 Fan Zhang, PhD; Jeffrey Harrison, PhD Chad Littrell, MS, MBA, University of Florida Lab Presentation Dendrimers for selective drug delivery in glioblastoma
8/18/2023 John Ligon, MD, PhD Christian Capitini, MD, University of Wisconsin Guest Speaker Targeting GD2: CAR T vs. NK cells

Fall 2023 Schedule

Dates HOST SPEAKER/AUTHOR FORUM TALK TITLE
9/8/2023 Elias Sayour, MD, PhD Christiano Marconi, University of Florida Journal Club Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
9/15/2023 Mariza Miranda, PhD Omar Zid, CEO, EasyPanel Workshop EasyPanel: a new tool to develop flow panel
9/22/2023 Elias Sayour, MD, PhD Yodarlynis Campaneria, University of Florida Journal Club Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
10/13/2023 Elias Sayour, MD, PhD Leighton Elliot, MD, MSE, University of Florida Lab presentation Using superparamagnetic iron oxide nanoparticles to characterize and augment immunotherapy vaccines for cancer
10/20/2023 Wells Brain Tumor Center BioRender Workshop BioRender “Top Design Tips for Better Posters
10/27/2023 Elias Sayour, MD, PhD Paul Castillo, MD, University of Florida Lab presentation Unleashing Immunity Against Refractory Cancers

Spring 2024 Schedule

Dates HOST SPEAKER/AUTHOR FORUM TALK TITLE
1/12/2024 John A Ligon, MD Gabriel Jobin, University of Florida Journal Club Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
1/19/2024 John A Ligon, MD John A Ligon, MD, University of Florida Lab presentation Upcoming pediatric RNA-LP trials
2/16/2024 Loic Deleyrolle, PhD James R. Mansfield, Visiopharm Guest Speaker Visiopharm: Pathology image analysis software from H&E and IHC to multiplex and beyond
2/23/2024 Christina Von Roemeling, PhD Savannah Carpenter & Jeet Patel, University of Florida Journal Club Genetically engineered cerebral organoids model brain tumor formation
3/1/2024 Duane Mitchell, MD, PhD Changlin Yang, MD, University of Florida Journal Club Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties
3/8/2024 Wells Brain Tumor Center Jack Canfield, Mark Victor Hansen, & Les Hewitt Book Club The Power of Focus: How to Hit Your Business, Personal and Financial Targets with Absolute Confidence and Certainty
3/29/2024 John A Ligon, MD David Steffin, MD, Baylor College of Medicine, Texas Children’s Hospital Guest Speaker Optimizing GPC3-CAR T cells for solid tumors
4/5/2024 Mohammed Gbadamosi, PhD, Arlen Gyden, University of Florida Lab presentation Variant Pathogenicity Prediction in Cancer
4/12/2024 Christina Von Roemeling, PhD Christina Von Roemeling, PhD, University of Florida Lab presentation Sensitization of glioblastoma to anti-PD-1 immune checkpoint blockade throughAAV induced CXCL9 expression
4/19/2024 Duane Mitchell, MD, PhD Pallavi Tiwari, PhD, University of Wisconsin Guest Speaker Artificial Intelligence and Computational Imaging:Opportunities for Precision Medicine
4/26/2024 John A Ligon, MD Ramon C. Sun, PhD, University of Florida Guest Speaker Leveraging spatial metabolomics for cancer research
5/17/2024 Wells Brain Tumor Center Duane Mitchell, MD, PhD, University of Florida Annual report and vision statement Brain SPORE 2026 – Precision Immunotherapy for Refractory Brain Tumors
5/31/2024 Loic Deleyrolle, PhD Russell Mellen, PhD, Lumicks Guest Speaker Next Generation Binding: Measuring Cell Avidity to Fully Characterize Cell-CellInteractions and Understand Mechanism of Action for Cellular Therapies

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